AIM share code: SKIN

13 March 2019

Integumen PLC

("Integumen" or "Company")

Exercise of Options

Integumen announces that it has received notification from employee option holders to exercise 17,777,776 shares in the issued share capital of Integumen ("the Option Shares"). The consideration for the exercise of the Option Shares at nominal value of 0.01p amounts, in aggregate, to a cash value of £ 1,777.

The Option holders hold a further 1,111,111 warrants priced at 0.01p which expire on 5 November 2021. The Option Shares are expected to be admitted to trading on AIM on or about 18 March 2019 and will rank pari passu with the ordinary shares of the Company in issue.

Total voting rights

The Company's total issued capital, after the issue of the Option Shares, will be 474,450,802 ordinary shares. As the Company does not hold any shares in Treasury, this figure may be used by shareholders in the Company as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the share capital of the Company following Admission.

Contacts

About Integumen:

Integumen is a vertically integrated business, collaborating their Labskin technology platform with partners in artificial intelligence, clinical research, medical device and life science. These collaborators are building their own technology on top of the Labskin AI backbone. Labskin allows skin-care, health-care, pharmaceutical manufacturers and cosmetic companies to test their products on human-like skin in a real-world environment with full access to multiple state-of-the-art partner technologies.

The Company combines data analytics with access to therapeutic operational expertise and offers solutions to our clients, from regulatory approvals, right through to marketing fully tested ingredients that have been certified on our Laboratory grown living human tissue.