11 December 2018

Integumen plc

("Integumen" or "the Company")

Issue of Equity

Following approval of all resolutions at the General Meeting held on Friday 7 December 2018, at a board meeting held today a total of 86,681,850 new ordinary shares of 0.01p each were allotted comprising 42,045,450 Subscription Shares, 38,636,400 Placing Shares and 6,000,000 Settlement Shares (all terms as defined in the RNS announcement of 22 November 2018).

Admission of the above shares is expected on 12 December 2018.

Total Voting Rights

For the purpose of the Disclosure Guidance and Transparency Rules, the Company's total issued ordinary share capital following Admission will be 454,826,872 ordinary shares of 0.01p each. This figure may be used by shareholders as the denominator for the calculations by which they will determine if they are required to notify their interest in, or a change to their interest in, the Company under the Disclosure Guidance and Transparency Rules.